Deep in the California woods on an evening in late August, Jane Pearson is camping with her husband Leo and their five-year-old son Benjamin. At that moment, every single person with a Y chromosome vanishes around the world. Children, adults, even fetuses are gone in an instant. Leo and Benjamin are gone. After the Disappearance, Jane forces herself to enter a world she barely recognizes, one where women must create new ways of living while coping with devastating grief.